業務内容

• 募集の背景、プロジェクトの説明

  This post is based in the Institute of Medical Sciences in the School of Medicine, Medical Science and Nutrition at the University of Aberdeen. The successful applicant will primarily work with Dr Takashi Kubota, who specialises in chromosome biology research and particularly in transcription in pathogenic fungi. The successful candidate will become an integral member of the Aberdeen Fungal Group, a dynamic consortium of six laboratories dedicated to advancing the frontiers of fungal research, and also closely work with Chromosome & Cellular Dynamics Group.

  https://www.abdnjobs.co.uk/vacancy/research-fellow-541498.html

• 仕事内容・職務内容

  We are recruiting for an exceptional individual as a Postdoctoral Research Fellow to work on the ‘How transcriptional regulation governs fungal drug resistance’ project funded by BBSRC.
  
  Antifungal drug resistance is a serious clinical and societal problem when using drugs to treat infections in humans and other animals. A common cause of drug resistance is overexpression of 'efflux pump' genes, which greatly reduce the effectiveness of drugs by pumping them out of cells.
  
  
  
  In this project, we will elucidate how expression of drug efflux pump genes is controlled in the pathogenic fungus Candida glabrata. C. glabrata infection is associated with high mortality in individuals with compromised immunity. C. glabrata is particularly deadly as a fungal pathogen because it has low susceptibility to azole antifungal agents, and easily develops drug resistance due to overproduction of efflux pumps. Preventing overexpression of these efflux pump genes is one good approach to ensure C. glabrata can be killed by existing antifungal drugs. However, overproduction mechanism of the pumps is not understood sufficiently well for us to prevent it.

• 配属部署

  Existing departments

  Institute of Medical Sciences, University of Aberdeen