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Postdoctoral fellowship at NIH to study Polo kinases orchestrating cell division and tumorigenesis
National Institutes of Health
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The National Institutes of Health (NIH) is the biggest biomedical research facility located in Bethesda, Maryland, U. S. A. I have been directing an independent research program at the National Cancer Institute (NCI) within NIH for the past 20 years.

Research title: Investigating the architecture and function of centrosomal self-assemblies in normal and disease state using biochemical and cell biological approaches

A postdoctoral fellowship is available to study the function of mammalian polo-like kinase 4 and 1 (Plk4 and Plk1) that play central roles in regulating various biological events, including centriole duplication, bipolar spindle formation, chromosome segregation, cell division, and proliferation. Dysregulation of Plk4/Plk1-dependent processes is tightly linked to the development of aneuploidy and cancer. During the past several years, we have been taking biochemical and cell biological approaches, including super-resolution imaging, single molecule tracking, and in vitro reconstitution to delineate the molecular bases of governing Plk4/Plk1's functionality on the centrosomal architecture, the deregulation of which can lead to the development of many human diseases, including cancers.

Fellows who have an expertise in the field of biochemistry and cell biology with a keen interest in learning about the organization and function of the centrosome and their relevance to pathophysiological disorders are encouraged to apply. Applicants should have a Ph.D. (or expected to receive a Ph.D.) or M.D. equivalent at the time of joining the lab and have achieved the degree less than 3 years ago.

Recent representative papers:
1.Kim, T.-S., et al., 2019. Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat. Comm. 10: 1151. Featured article (Editors' Highlights).
2.Park, J.-E., et al., 2019. Phase separation of polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat. Comm. 10: 4959.
3.Wei, Z., et al., 2020. Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplication. Mol. Cell. Biol. 40:e00535. Featured article (Cover art)
4.Ahn, J. I., et al., 2020. Phase separation and versatile capacity of pericentriolar scaffold proteins drive the formation of higher-order self-assemblies at human centrosomes. Cell Cycle. Nov 18:1-21.
5. Lee, K. S., et al., 2020. A self-assembled cylindrical platform for Plk4-induced centriole biogenesis. Open Biol. 10:200102 (Review). Featured article (Cover art)

Number of positions available: 1
Starting date: As soon as possible
Application deadline: March 31, 2022
Work Location:
National Cancer Institute
National Institutes of Health
9000 Rockville Pike, Building 37 Room 3118
Bethesda, MD 20892

Research field
Biological Sciences
All Biological Science
All Biology
Job type
Researcher/Postdoc level
Employment status
Work location
Others - Outside of Japan/ Work at home etc. 

Applicants should have a Ph.D. (or expected to receive a Ph.D.) or M.D. equivalent at the time of joining the lab or have achieved the degree less than 2 years ago.

Fellows who have an expertise in classical cell biology and biochemistry with a keen interest in various super-resolution imaging and single molecule tracking approaches are encouraged to apply.


Job title: Postdoctoral fellow

Salary starts at $59,900 with an increase proportional to applicant's experience

Work hours: 9:00-18:00, 5 days/week; holidays observed.

Insurance: Full insurance for individual or family is provided

Period of employment: up to 5 years

Application period
2021/10/18 -  2022/03/31 Deadline for receipt
/notification of result
/contact details

Application documents: Please send CV and three names of references to Dr. Kyung Lee (Email: No health check is required.

Selection will be carried out as soon as any application is received. Selected candidate will be notified by email after any decision is being made.

Dr. Kyung Lee
Senior Investigator
Laboratory of Metabolism
National Cancer Institute
National Institutes of Health
9000 Rockville Pike, Building 37 Room 3118
Bethesda, MD 20892

For information about our research program, please visit:

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