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[Laboratory]
Laboratory for Vascular Morphogenesis
RIKEN Center for Biosystems Dynamics Research
(Team Leader: Phng Li-Kun)

[Research Field]
The RIKEN Center for Biosystems Dynamics Research (BDR) views the functions of molecules, cells, and organs that support all life stages of organisms as a dynamic system, and aims to elucidate developmental, growth and aging phenomena as well as apply their findings to develop regenerative medicine and diagnostics, thereby contributing to the extension of healthy life expectancies.

The Laboratory for Vascular Morphogenesis is interested in understanding the fundamental morphogenetic principles of how endothelial cells behave and coordinate with each other and the perivascular environment to generate a well-patterned network of blood vessels. Using the zebrafish as a model system, we seek to understand how endothelial cell shape plasticity is regulated to drive vessel formation and remodelling. We also aim to understand endothelial cell mechanoresponse to haemodynamic forces in the control of vessel morphology and patterning. By unravelling the basic mechanisms of how endothelial cells build blood vessels of specific size and network pattern, we aim provide insights into how vascular malformations arise.
For more information on lab research activities, please refer to the above "Job posting URL"

[Job title and Job description]
Job title, available positions:
Research Scientist or Postdoctoral Researcher

Position-specific tasks are as follows:

Research Scientist:
Carry out research and other work in accordance with research themes of the team.

Postdoctoral Researcher:
Carries out research and other work in accordance with laboratory research themes under the mentorship and training of supervisors.

Number of positions:
1 position

Job description:
We are recruiting a researcher to join the “Mechanochemical feedback and emergence of tissue function in luminal tissues" project (PI: Li-Kun Phng), a research group within the JSPS Transformative Research Area (A) group grant “Mechanical self-transformation of living systems" (PI:Fumio Motegi, Hokkaido University).
Please visit the website below for more information on “Mechanical self-transformation of livingsystems":
https://multicellular-mechanics.org/en/

The successful candidate will develop and implement new methodologies to characterize the effects of haemodynamic forces in regulating cellular and subcellular processes using zebrafish and microfluidics. The eventual goal is to understand how the synergy of haemodynamic forces and endothelial cell mechanics shape vascular tubes of correct morphology and optimal size and pattern.The successful candidate is also expected to design and manage his/her research experiments; present research findings; write grants and research papers; and communicate and collaborate with researchers in and out of the laboratory.

[Work location]
Branch and address:
RIKEN Center for Biosystems Dynamics Research (Kobe Campus-East-West)
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047 (Developmental Biology Buildings)

[Start of Employment]
As soon as possible (negotiable)

[Keyword]
Blood vessel formation
Endothelial cell dynamics
Zebrafish

Research Scientist:
A PhD holder in the area related to the Job description.
Postdoctoral Researcher:
A PhD holder who earned a doctorate within the past 5 years in the area related to the Job description.

We seek a candidate with a strong interest in unravelling mechanisms governing tissue morphogenesis and patterning. He or she should have relevant experience in cell biology, developmental biology, biophysics and/or bioengineering with skills in quantitative live imaging. The successful candidate must have a PhD degree prior to joining the lab.

For details about “salary and benefits", please refer to the above “Job posting URL".

[Application and required documents]
Required documents:
Please refer to the above “Job posting URL" regarding the “Required documents"

How to apply:
The above documents except the recommendation letters combined into a single ZIP file should be uploaded to the website:
Please refer to the above “Job posting URL"

･The file name of the ZIP should contain your contact email address.
･After you uploaded the ZIP file, please let us (kobe-jobs [at] riken.jp) know the file name of the uploaded file.

Recommendation letters must be directly submitted from the referees to the website with the file name "Laboratory for Vascular Morphogenesis [applicant's name] (Recommendation letter)". Please specify the applicant's name, referee's name and contact information in the recommendation letter.
Please refer to the above “Job posting URL"

･After the referees uploaded the recommendation letter, please let us (kobe-jobs [at] riken.jp) know the file name of the uploaded file.
･If a confirmation email is not received within 7 days after submission, please contact: kobe-jobs [at] riken.jp.

*Please understand that we will not return application documents.

Deadline:
Applications will be evaluated on a rolling basis until the position is filled.

[Selection process]
Selection will be made based on application screening and interview. After documents screening, only successful applicants will be invited for interview.

*We do not answer to questions regarding contents of the examination.

[Contact Information]
For inquiries on this open position, please contact below by email:
Human Resources Section, Kobe Administrative Division, Kobe Branch, RIKEN
kobe-jobs [at] riken.jp

*If you have any research-related questions, please contact likun.phng [at] riken.jp (Laboratory for Vascular Morphogenesis, Dr. Li-Kun Phng)

Handing Personal Data:
Submitted documents are strictly protected under the RIKEN Privacy Policy and will be used only for the purpose of applicant screening. Personal information will not be disclosed, transferred or loaned to a third party under any circumstances without just cause.

2022/11/17:Updated as of Nov 17, 2022: "Job description" and "Qualification"