Job description

• Background of the recruitment and description of the project

  The World Premier International Research Center Initiative (WPI) program promotes the establishment of research centers that attract world-class researchers, implement changes in the existing academic system, and forge new academic fields.
  
  Bio2Q addresses the question of how human homeostasis is regulated by the epithelial, immune, neural, and metabolic systems, with an emphasis on microbiome analysis. The center will thereby establish a new form of life science aimed at understanding human multiorgan homeodynamics at resolutions higher than those achieved so far. Bio2Q will implement quantum computing together with artificial intelligence (AI) to analyze multiomics data and elucidate the multiorgan interaction pathways underlying human disease. Furthermore, we aim to also establish a reverse-translation workflow to decipher the causal relationships within the newly uncovered pathways.
  
  In line with the WPI missions of globalization and diversity, when applicants are judged to be equally qualified based on fair and impartial criteria, international and female applicants will be given preference. The official language of the center is English.
  

• Work content and job description

  Professor Nadinath Nillegoda’s lab specializes in Cell Biology (mammalian), Molecular Biology, and Biochemistry, with a strong focus on developing novel mouse models to investigate protein quality control mechanisms and pathways that help cell repair after protein damage, disease pathogenesis, and therapeutic strategies.
  
  Prof. Nillegoda’s multidisciplinary research is pioneering the study of primate-specific adaptations in proteostasis (protein homeostasis) and their role in cell repair mechanisms following proteotoxic stress/damage. Understanding these unique adaptations is crucial for promoting healthy aging in humans, offering insights into cellular resilience and disease prevention. At Bio2Q, his research aims to enhance intestinal barrier integrity, mitigate dysbiosis-induced proteotoxic stress, and improve gut health. Given the increasing prevalence of inflammatory bowel disease (IBD), metabolic disorders, and age-related protein misf
  
  We are seeking a skilled, energetic, and dedicated candidate with extensive experience in mouse and/or cell culture research. Required experimental skills include mouse colony maintenance, breeding, genotyping, handling, dosing (oral gavage, intraperitoneal, subcutaneous, and intravenous injections), tissue dissection, organ harvesting, perfusion, primary cell culture generation, immunohistochemical analysis, and assistance with ethics applications. Having experience in mammalian cell culture, including techniques such as transfection is a plus.
  
  The candidate is expected to assist with general lab maintenance tasks, work directly with the Principal Investigator, and collaborate effectively with team members to achieve experimental goals. The Nillegoda laboratory works closely with the neighboring laboratory of Professor Kenya Honda, a world-renowned expert in the gut microbiome at Bio2Q. The candidate should be open to learning new techniques e.g. in animal experiments and cell biology as needed to support ongoing research.
  

Job description

• Background of the recruitment and description of the project

  The Institute for Chemical Reaction Design and Discovery (ICReDD), Hokkaido University, as a global research center based on the “World Premier International Research Center Initiative (WPI) , supported by Japan's Ministry of Education, Culture, Sports, Science and Technology (MEXT),” constructs an international research environment which gathers world-leading researchers and establishes a research environment that integrates computational, information and experimental sciences, in order to establish a new academic field “Chemical Reaction Design and Discovery”, to provide substantial knowledge on chemical reactions that efficiently develop chemical reactions and materials for the future necessity, and to sustainably cultivate human resources engaged in the field of “Chemical Reaction Design and Discovery”.

• Work content and job description

  [Job Description]
  (Just after hiring) In the ICReDD Komatsuzaki group, the following research will be carried out mainly by collaboration with computational, information and experimental scientist.
  (1) Study on Measurement Informatics such as molecular spectroscopy
  (2) Study on optimization of chemical reaction conditions including the design of catalysts using reinforcement learning and multi-objective optimization
  (3) Study on state space network and its kinetic projection combined with electronic structure theories and Machine Learning (ML) potential
  (Scope of change) No change expected.

Job description

• Background of the recruitment and description of the project

  WPI-IRCN is seeking post-doctoral research fellows (AI Incubator) who specialize in machine learning/artificial intelligence/statistics and/or computational/mathematical neuroscience and are extremely motivated and enthusiastic to generate neuro-inspired artificial intelligence (A.I.), working interdisciplinary with multiple PIs.

• Work content and job description

  IRCN has established an "AI Incubator (led by Prof. Kazuyuki Aihara)" within IRCN. The selected candidates will participate in one or more team science activities as a member of the "AI Incubator" to integrate breakthrough discoveries made through our Team Science approach into innovative neuro-inspired AI:
  
  (1) Neuromodulation/Reinforcement Learning (Haruo Kasai, Kazuyuki Aihara & Shin Ishii)
  (2) Critical Period Mechanisms (Takao Hensch, Kazuyuki Aihara, Yukiko Gotoh, Takamitsu Watanabe & Yasushi Okada)
  (3) Social Learning (Yukie Nagai, Kazuyuki Aihara, Takao Hensch, Shoji Takeuchi & Sho Tsuji)
  (4) Intrinsic Activity (Kenichi Ohki, Kazuyuki Aihara, Takamitsu Watanabe, Hideki Nakayama, Kiyoto Kasai, Zenas Chao, Takao Hensch & Gohei Tanaka)
  (5) Predictive Coding (Zenas Chao, Kenichi Ohki, Yukie Nagai, Kazuyuki Aihara, Kiyoto Kasai & Hirokazu Takahashi)
  
  Below is a list of potential projects. Details of each project are available on the URL of this job posting.
  (a) Neuro-inspired AI using reservoir computing and mathematical engineering
  (b) Neuro-inspired AI using reservoir computing and dynamical systems theory
  (c) Predictive coding in neuro-machine hybrid system
  (d) AI-neuro hybrid modeling of neuromodulation
  (e) Neuro-inspired AI using deep learning and brain analysis
  
  General Remarks
  The selected candidates are strongly encouraged to participate in one or more above mentioned projects.
  
  Scope of change: The University may order employees to be reassigned to different positions, or order them to take up additional positions or to work on an external assignment.

Job description

• Background of the recruitment and description of the project

  We seek an exceptional researcher to pursue the following research subjects as an "Assistant Professor" at NanoLSI.
  The Shibata Laboratory specializes in the bio-applications of high-speed atomic force microscopy (HS-AFM).
  
  Representative Papers
  1. M. Shibata and H. Nishimasu et al., “Real-space and real-time dynamics of CRISPRCas9 visualized by high-speed atomic force microscopy.” Nat. Commun. 8, 1430 (2017).
  2. L. Puppulin et al., “Dynamics of target DNA binding and cleavage by Staphylococcus aureus Cas9 as revealed by high-speed atomic force microscopy.” ACS Nano, 17, 4629-4641 (2023).
  3. S. Tsujioka et al., “Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy.” Sci. Adv. 9, eadh1069 (2023).
  4. S. Morioka et al., “High-speed atomic force microscopy reveals the nucleosome sliding and DNA unwrapping/wrapping dynamics of tail-less nucleosomes.” Nano Lett., 24,
  5246‒5254 (2024).
  5. A. Sumino et al., “High-speed atomic force microscopy reveals fluctuations and dimer splitting of the N-terminal domain of GluA2 ionotropic glutamate receptor-auxiliary subunit complex.” ACS Nano 18, 25018-25035 (2024).
  

• Work content and job description

  <Job Description＞
  A candidate will join the Shibata Laboratory as a specially-appointed Assistant Professor to participate in the JST ERATO “TOYOTA Plant Sensory Transduction” project (launched in FY2024)[https://www.jst.go.jp/erato/en/research_area/ongoing/jpmjer2403_en.html].
  The role involves conducting research on plant contact and odor sensing and signaling systems using biochemical, molecular genetic, and protein scientific methods, as well as publishing papers. The NanoLSI at Kanazawa University provides a research institute with an outstanding environment supported by the World Premier International Research Center Initiative (WPI). AFM experiments are not required for this position.