求人公募情報閲覧
勤務地 : Kanto district - Tokyo
公開開始日 : 2025/07/24
Call for a Postdoctoral Fellow for Professor Nadinath Nillegoda’s Lab at Keio University WPI-Bio2Q
D125071879
Keio University
研究分野 : Others - Others - Human biology, Microbiology, Cell biology(Protein damage and cell repair), Structural biology, Molecular biology(Primate proteostasis, Protein disaggregation), Microbiome, Neural science, Immunology, Oncology, Genome science, Pharmacy, Quantum computing science, Computer science, Information science, Artificial intelligence
Research/Educational Assistance : Contract employee - Nontenured - Non-tenure track - Probationary period absent
業務内容
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募集の背景、プロジェクトの説明
Our laboratory’s overarching research focuses on protein quality control pathways that help maintain cellular proteostasis (protein homeostasis) and promote cell repair after protein damage. My group pioneers in the emerging field of primate proteostasis, being the first to investigate how primate-specific adaptations in the proteostasis network influence cell repair and deepen our understanding of human diseases related to protein aggregation and aging. In close collaboration with world-renowned scientists at Bio2Q, we will lead research into intestinal microbiota-epithelial crosstalk through the lens of proteostasis (from both the host and microbial sides), aiming to uncover novel primate-specific mechanisms and pathways that protect our gut barrier integrity after proteotoxic damage caused by dysbiosis. Proteotoxic stress in the intestinal epithelial tissue, often triggered by metabolites released during microbial imbalances, can lead to massive oxidative damage to proteins, resulting in the formation of toxic aggregates. These toxic aggregates can disrupt cell function, often leading to cell death, which could further impair gut barrier function and exacerbates inflammatory diseases such as inflammatory bowel disease (IBD), colitis, and metabolic disorders. Our work has the exciting potential to drive advancements in treating these gut-related diseases and improve gut health. One main area of research delves into exploring strategies to enhance protein disaggregation (aggregate solubilization) in our cells to counteract toxicities associated with protein aggregation. We have uncovered several novel primate-specific protein quality control pathways that boost the assemble of protein disaggregases (molecular machines that disassemble aggregated proteins).
https://www.bio2q.keio.ac.jp -
仕事内容・職務内容
We are currently using multidisciplinary approaches (some through collaborations) including cell biology, molecular biology, evolutionary biology, biochemistry and structural biology, machine learning with a strong focus on characterizing novel mouse models with enhanced protein disaggregation function to investigate the impact of these primate-specific adaptations in proteostasis in disease (including dysbiosis related disorders and neurodegeneration) and aging. Therefore, we are seeking a talented, dedicated, and energetic Postdoctoral Fellow with extensive experience in mouse and cell biology, molecular biology, cell/tissue imaging techniques to lead new research initiative(s) that study the role of the primate-specific adaptations in protein disaggregation and their impact on aggregate solubilization/cell repair along the gut-brain axis. The applications of this work center on combating dysbiosis and neurodegeneration. This exciting and high-impact research direction presents unique opportunities for rapid, groundbreaking discoveries that could significantly enhance healthy aging. While prior experience in proteostasis, gut microbiome, neuroscience, stem cell biology or related fields is advantageous, it is not required.
The candidate will work closely with the Principal Investigator and collaborate effectively with team members to achieve experimental goals. Our team closely collaborates with world-renowned experts in the gut microbiome, stem cells and organoid biology and neuroscience at Bio2Q to achieve the above-mentioned research goals. These collaborations offer the candidate access to cutting-edge techniques and skills for use in his/her research. Importantly, a key focus will be on developing the candidate’s career path in science. Additionally, the candidate will have the opportunity to undertake research stays in Switzerland and the USA to further enhance their research objectives. -
配属部署
Existing departments
Professor Nadinath Nillegoda’s Lab, Keio University WPI Human Biology-Microbiome-Quantum Research Center (Bio2Q)
職種
- Research/Educational Assistance
研究分野
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Others - Others
Human biology, Microbiology, Cell biology(Protein damage and cell repair), Structural biology, Molecular biology(Primate proteostasis, Protein disaggregation), Microbiome, Neural science, Immunology, Oncology, Genome science, Pharmacy, Quantum computing science, Computer science, Information science, Artificial intelligence
給与
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Annual Salary : 6 million yen ~ 7 million yen
The annual salary will correspond to years of experience, ability, and performance.
Model annual salary: 6,000,000 – 7,000,000 JPY
勤務時間
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Working hours :08:30-17:00
Break time :11:30-12:30
Holidays : Days off include Sundays, national holidays, year-end/New Year holidays, and Keio University holidays (January 10, etc.).
Overtime and other explanations : Working on Sundays and holidays may sometimes be required.
募集要項
応募資格
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応募に必要な学歴・学位
Others
Applicants must have been awarded a PhD in a relevant field (e.g. Proteostasis, stem cell biology, gut microbiome, neuroscience, or related fields. Candidates with a strong background in cell biology and mouse studies will also be considered).
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説明
Applicants must fulfill the following requirements:
【Research accomplishments】 A good track record of research achievements. A first-author research article in a reputable journal is recommended. Candidates with first-author manuscripts currently in review will also be equally considered.
【Expert knowledge & skills】 Demonstrated expertise in areas related to mouse models, cell biology, molecular biology, cell/ tissue imaging. Having exposure in proteostasis, gut microbiome, stem cell biology and/or neuroscience research will be advantageous, but not necessary.
【Interest & motivation】 A strong interest in the research outlined and the ability to independently design, execute, and analyze experiments.
【Communication skills】 Verbal and written communication skills in English are essential, as the candidate will be required to present findings to both internal teams and external collaborators.
【Collaboration & coordination】 Excellent interpersonal skills and the ability to coordinate and collaborate effectively with other research teams, both within and outside the institution.
【Basic computer skills】 Proficiency in standard computer applications and experience with data analysis software.
【Adaptability & problem-solving】 The ability to think critically and independently, while adapting to new challenges and solving complex problems in experimental design and execution.
【Passion for career development】 We are committed to the professional growth of our postdoctoral fellows. The candidate should have a clear interest in pursuing a successful academic or industry career a
雇用形態
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Contract employee
契約期間
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Nontenured - Non-tenure track
(1) The contract is a three-year fixed-term employment contract and is subject to review each fiscal year. The contract is eligible for renewal based on performance and mutual agreement between employer and employee.
(2) The renewable term is subject to change depending on the continuation of the WPI program, Bio2Q's management situation, budget situation, and other factors. In principle, the contract will not be renewed beyond the age of 65.Probationary period absent
勤務地
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〒160-8582
Tokyo
Shinjuku-ku, Shinanomachi
The successful applicant will work at the host laboratory within the Bio2Q research center located at 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
待遇
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各種制度
Transportation expenses : available
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加入保険
Employees' Health Insurance : available
Employees' Pension Insurance : available
Worker's accident insurance : available
Employment insurance : available
応募上の配慮
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面接実施に関しての配慮（海外など遠方にお住まいの方、他）
For those unable to come in person, interviews may be conducted online.
採用人数
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求人内容補足説明
The starting dates are negotiable.
1 person(s)
Hiring date : 2025/11/01
Starting date : 2025/11/01
募集期間
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2025/07/24~2025/09/30 Deadline for receipt
Selection process will be conducted on first-come-first-served basis and it will be closed once we find an appropriate candidate.
応募方法
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応募書類
Application Form : Online Submission*All applications must be submitted in English.Other online application forms
*All applications must be submitted in English.
1. CV
2. List of research activities, including full list of publications, achievements, etc.
3. Motivation letter including a description of how you plan to contribute to Bio2Q.
4. Recommendation letter(s) -
応募書類の返却
We will dispose of all application documents responsibly.
※(at)を@に変更して送信してください。
選考・結果通知
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選考内容
Applicants who pass the initial application-based screening will be interviewed in English. Applicants will be responsible for travel and accommodation expenses incurred during the interview selection process.
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結果通知方法
We will notify you of the results of your selection by email.
連絡先
Keio University
Office of Research Development and Sponsored Projects, WPI (Bio2Q)
Personnel and Public Relations Team
bio2q_recruiting(at)info.keio.ac.jp
※(at)を@に変更して送信してください。
備考
